BDBM50271212 CHEMBL3715238

SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1CC1CC1)-c1cnc(N)c(c1)C(F)(F)F)C1COC1

InChI Key InChIKey=IRPVABHDSJVBNZ-QWHZDKJVSA-N

Data  1 KI  13 IC50  2 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50271212   

TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271212(CHEMBL3715238)
Affinity DataKi:  4nMAssay Description:Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 12(Mus musculus)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271212(CHEMBL3715238)
Affinity DataEC50:  457nMAssay Description:Inhibition of DLK in CD-1 mouse DRG neuron assessed as axonal protection pre-incubated for 2 hrs before NGF deprivation for 16 to 20 hrs by Campenot ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 7(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271212(CHEMBL3715238)
Affinity DataIC50:  665nMAssay Description:Inhibition of recombinant GST-tagged human EphA7 cytoplasmic domain expressed in baculovirus expression system by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271212(CHEMBL3715238)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant full length His-tagged human JNK1alpha1 expressed in baculovirus expression system by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271212(CHEMBL3715238)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant full length His-tagged human JNK2 (473 to end residues) expressed in baculovirus expression system at by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271212(CHEMBL3715238)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant full length GST-tagged human JNK3 expressed in baculovirus expression system by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271212(CHEMBL3715238)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of recombinant human GST-tagged MLK1 expressed in baculovirus expression system by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 10(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271212(CHEMBL3715238)
Affinity DataIC50:  5.15E+3nMAssay Description:Inhibition of recombinant human full length GST-tagged MLK2 expressed in baculovirus expression system by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271212(CHEMBL3715238)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human full length GST-tagged MLK3 expressed in baculovirus expression system by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271212(CHEMBL3715238)
Affinity DataIC50:  238nMAssay Description:Inhibition of recombinant His-tagged human FLT3 cytoplasmic domain expressed in baculovirus expression system by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271212(CHEMBL3715238)
Affinity DataIC50:  383nMAssay Description:Inhibition of recombinant His-tagged human TrkA cytoplasmic domain (441 to 796 residues) expressed in baculovirus expression system by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271212(CHEMBL3715238)
Affinity DataIC50:  448nMAssay Description:Inhibition of recombinant His-tagged human AXL (473 to end residues) cytoplasmic domain expressed in insect cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271212(CHEMBL3715238)
Affinity DataIC50:  144nMAssay Description:Inhibition of doxycycline inducible human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-bas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 13(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271212(CHEMBL3715238)
Affinity DataKd:  120nMAssay Description:Binding affinity to full length wild type human LZK (M1 to W966 residues) expressed in mammalian cells by KINOMEscan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271212(CHEMBL3715238)
Affinity DataKd:  5.10nMAssay Description:Binding affinity to full length wild type human DLK (M1 to P859 residues) expressed in mammalian cells by KINOMEscan assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271212(CHEMBL3715238)
Affinity DataIC50:  1.22E+3nMAssay Description:Inhibition of recombinant His-tagged human CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus expression system by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyotonin-protein kinase(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50271212(CHEMBL3715238)
Affinity DataIC50:  1.38E+3nMAssay Description:Inhibition of full length recombinant human DMPK expressed in baculovirus expression system by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed