BDBM50271275 1H-Indazol-7-amine::1H-indazol-7-amine, 1::CHEMBL463676

SMILES Nc1cccc2cn[nH]c12

InChI Key InChIKey=OTFFCAGPSWJBDK-UHFFFAOYSA-N

Data  5 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50271275   

TargetGenome polyprotein [1658-1692](Hepatitis C virus)
Astex Pharmaceuticals

LigandPNGBDBM50271275(1H-Indazol-7-amine | 1H-indazol-7-amine, 1 | CHEMB...)
Affinity DataIC50: >5.00E+6nMT: 2°CAssay Description:The protease activity of the full-length NS3-NS4a and the protease domain were measured using a FRET-based assay using a peptide substrate derived fr...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Université

Curated by ChEMBL
LigandPNGBDBM50271275(1H-Indazol-7-amine | 1H-indazol-7-amine, 1 | CHEMB...)
Affinity DataIC50:  8.50E+5nMAssay Description:Inhibition of rat brain recombinant nNOSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Uned

Curated by ChEMBL
LigandPNGBDBM50271275(1H-Indazol-7-amine | 1H-indazol-7-amine, 1 | CHEMB...)
Affinity DataIC50:  1.15E+5nMAssay Description:Inhibition of recombinant NOS1 assessed as citrulline formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Université

Curated by ChEMBL
LigandPNGBDBM50271275(1H-Indazol-7-amine | 1H-indazol-7-amine, 1 | CHEMB...)
Affinity DataIC50:  4.00E+5nMAssay Description:Inhibition of bovine recombinant eNOSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Université

Curated by ChEMBL
LigandPNGBDBM50271275(1H-Indazol-7-amine | 1H-indazol-7-amine, 1 | CHEMB...)
Affinity DataIC50:  1.10E+5nMAssay Description:Inhibition of mouse recombinant iNOSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed