BDBM50273426 CHEMBL515980::N-(4-Phenoxybenzenesulfonyl)-N-hydroxycarbonylmethyl-D-valinehydroxamicAcid

SMILES CC(C)[C@@H](N(CC(O)=O)S(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO

InChI Key InChIKey=KBZNOZAJAJRTII-GOSISDBHSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50273426   

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Instituto Superior TéCnico

Curated by ChEMBL
LigandPNGBDBM50273426(CHEMBL515980 | N-(4-Phenoxybenzenesulfonyl)-N-hydr...)
Affinity DataIC50:  0.770nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Instituto Superior TéCnico

Curated by ChEMBL
LigandPNGBDBM50273426(CHEMBL515980 | N-(4-Phenoxybenzenesulfonyl)-N-hydr...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Instituto Superior TéCnico

Curated by ChEMBL
LigandPNGBDBM50273426(CHEMBL515980 | N-(4-Phenoxybenzenesulfonyl)-N-hydr...)
Affinity DataIC50:  59nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Instituto Superior TéCnico

Curated by ChEMBL
LigandPNGBDBM50273426(CHEMBL515980 | N-(4-Phenoxybenzenesulfonyl)-N-hydr...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human recombinant MMP2 transfected in mouse melanoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Instituto Superior TéCnico

Curated by ChEMBL
LigandPNGBDBM50273426(CHEMBL515980 | N-(4-Phenoxybenzenesulfonyl)-N-hydr...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of MMP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetElastase(Pseudomonas aeruginosa)
Uit - The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50273426(CHEMBL515980 | N-(4-Phenoxybenzenesulfonyl)-N-hydr...)
Affinity DataIC50:  8.20E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa pseudolysin using Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide as substrate after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-16(Homo sapiens (Human))
Instituto Superior TéCnico

Curated by ChEMBL
LigandPNGBDBM50273426(CHEMBL515980 | N-(4-Phenoxybenzenesulfonyl)-N-hydr...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of MMP16More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Instituto Superior TéCnico

Curated by ChEMBL
LigandPNGBDBM50273426(CHEMBL515980 | N-(4-Phenoxybenzenesulfonyl)-N-hydr...)
Affinity DataIC50:  2.29E+3nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Instituto Superior T£Cnico

Curated by ChEMBL
LigandPNGBDBM50273426(CHEMBL515980 | N-(4-Phenoxybenzenesulfonyl)-N-hydr...)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of MMP3 using Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 as substrate preincubated for 4 hrs measured every 15 secs for 20 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetElastase(Pseudomonas aeruginosa)
Uit - The Arctic University Of Norway

Curated by ChEMBL
LigandPNGBDBM50273426(CHEMBL515980 | N-(4-Phenoxybenzenesulfonyl)-N-hydr...)
Affinity DataIC50:  3.36E+5nMAssay Description:Inhibition of Pseudomonas aeruginosa pseudolysin using Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys-(Dnp)-OH as substrate after 1 hr by fluorescence assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Instituto Superior TéCnico

Curated by ChEMBL
LigandPNGBDBM50273426(CHEMBL515980 | N-(4-Phenoxybenzenesulfonyl)-N-hydr...)
Affinity DataIC50:  0.330nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed