BDBM50275886 8-(5-(2-amino-5-(thiophen-2-yl)phenylcarbamoyl)pyridin-2-yl)-N-ethyl-2,8-diazaspiro[4.5]decane-2-carboxamide::CHEMBL470581

SMILES CCNC(=O)N1CCC2(C1)CCN(CC2)c1ccc(cn1)C(=O)Nc1cc(ccc1N)-c1cccs1

InChI Key InChIKey=UZFJLATVXCCZGS-UHFFFAOYSA-N

Data  1 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50275886   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275886(8-(5-(2-amino-5-(thiophen-2-yl)phenylcarbamoyl)pyr...)
Affinity DataKi:  460nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275886(8-(5-(2-amino-5-(thiophen-2-yl)phenylcarbamoyl)pyr...)
Affinity DataEC50:  5.00E+3nMAssay Description:Activity at human ERG expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275886(8-(5-(2-amino-5-(thiophen-2-yl)phenylcarbamoyl)pyr...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human HDAC1 expressed in mammalian cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed