BDBM50276015 CHEMBL509161::N-(3,5-dimethylphenyl)-4-(thiazol-2-yl)pyrimidin-2-amine

SMILES Cc1cc(C)cc(Nc2nccc(n2)-c2nccs2)c1

InChI Key InChIKey=GVWNNKNAVOPJNV-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50276015   

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50276015(CHEMBL509161 | N-(3,5-dimethylphenyl)-4-(thiazol-2...)
Affinity DataKi:  8nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50276015(CHEMBL509161 | N-(3,5-dimethylphenyl)-4-(thiazol-2...)
Affinity DataKi:  419nMAssay Description:Inhibition of ZAP70 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50276015(CHEMBL509161 | N-(3,5-dimethylphenyl)-4-(thiazol-2...)
Affinity DataKi:  1.06E+3nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50276015(CHEMBL509161 | N-(3,5-dimethylphenyl)-4-(thiazol-2...)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50276015(CHEMBL509161 | N-(3,5-dimethylphenyl)-4-(thiazol-2...)
Affinity DataIC50:  550nMAssay Description:Inhibition of SYK (unknown origin)-mediated FCepsilonRI signaling activity by mast cell degranulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed