BDBM50277067 1-(8-chloro-5-methoxy-2-(thiophen-2-yl)quinazolin-4-ylamino)-3-methyl-1H-pyrrole-2,5-dione::CHEMBL514875

SMILES COc1ccc(Cl)c2nc(nc(NN3C(=O)C=C(C)C3=O)c12)-c1cccs1

InChI Key InChIKey=FAZJTQVDAJDGAY-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50277067   

TargetTranscription factor p65(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50277067(1-(8-chloro-5-methoxy-2-(thiophen-2-yl)quinazolin-...)
Affinity DataEC50:  2.40E+3nMAssay Description:Induction of NFkappaB p65 nuclear translocation in HUVEC cells by immunostainingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM50277067(1-(8-chloro-5-methoxy-2-(thiophen-2-yl)quinazolin-...)
Affinity DataEC50:  310nMAssay Description:Potentiation of TNFalpha-induced NFkappaB p65 nuclear translocation in HUVEC cells by immunostainingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed