BDBM50277329 (S)-benzyl 1-(6-methoxyquinolin-8-ylamino)-1-oxo-6-(sulfamoylamino)hexan-2-ylcarbamate::CHEMBL473082

SMILES COc1cc(NC(=O)[C@H](CCCCNS(N)(=O)=O)NC(=O)OCc2ccccc2)c2ncccc2c1

InChI Key InChIKey=VBRYMHVURZBROJ-FQEVSTJZSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50277329   

TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50277329((S)-benzyl 1-(6-methoxyquinolin-8-ylamino)-1-oxo-6...)
Affinity DataIC50:  460nMAssay Description:Inhibition of human recombinant C-terminal FLAG-tagged HDAC1 expressed in baculovirus by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50277329((S)-benzyl 1-(6-methoxyquinolin-8-ylamino)-1-oxo-6...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of HDAC1 in human 293T cells after 16 hrs by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50277329((S)-benzyl 1-(6-methoxyquinolin-8-ylamino)-1-oxo-6...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human recombinant N-terminal histidine-tagged HDAC6 expressed in baculovirus by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed