BDBM50277714 2-(3-(7-hydroxy-4,5-dihydronaphtho[2,1-d]isoxazol-3-yl)propanamido)cyclohex-1-enecarboxylic acid::CHEMBL485196

SMILES OC(=O)C1=C(CCCC1)NC(=O)CCc1noc-2c1CCc1cc(O)ccc-21

InChI Key InChIKey=CEEDKNHIBNHBQW-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50277714   

TargetCytochrome P450 2C8(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277714(2-(3-(7-hydroxy-4,5-dihydronaphtho[2,1-d]isoxazol-...)
Affinity DataIC50:  4.40E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using montelukast substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277714(2-(3-(7-hydroxy-4,5-dihydronaphtho[2,1-d]isoxazol-...)
Affinity DataEC50:  19nMAssay Description:Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277714(2-(3-(7-hydroxy-4,5-dihydronaphtho[2,1-d]isoxazol-...)
Affinity DataIC50:  4nMAssay Description:Displacement of [3H]niacin from human GPR109A expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277714(2-(3-(7-hydroxy-4,5-dihydronaphtho[2,1-d]isoxazol-...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed