BDBM50284506 4-[5-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-3H-imidazol-4-yl]-pyridine::CHEMBL280317

SMILES CS(=O)(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1

InChI Key InChIKey=XEOVWJYINDYNSM-UHFFFAOYSA-N

Data  2 KI  4 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50284506   

TargetCasein kinase I isoform delta(Homo sapiens (Human))
Christian-Albrechts University Of Kiel

Curated by ChEMBL
LigandPNGBDBM50284506(4-[5-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl...)
Affinity DataKi:  39nMAssay Description:Binding affinity to CK1delta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCasein kinase I isoform alpha(Homo sapiens (Human))
Christian-Albrechts University Of Kiel

Curated by ChEMBL
LigandPNGBDBM50284506(4-[5-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl...)
Affinity DataKi:  650nMAssay Description:Binding affinity to CK1a1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Christian-Albrechts University Of Kiel

Curated by ChEMBL
LigandPNGBDBM50284506(4-[5-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl...)
Affinity DataIC50:  40nMAssay Description:Inhibition of P38alphaMAPK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))
Christian-Albrechts University Of Kiel

Curated by ChEMBL
LigandPNGBDBM50284506(4-[5-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl...)
Affinity DataKd:  100nMAssay Description:Binding affinity to CK1epsilon (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCasein kinase I isoform alpha-like(Homo sapiens (Human))
Christian-Albrechts University Of Kiel

Curated by ChEMBL
LigandPNGBDBM50284506(4-[5-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl...)
Affinity DataKd:  1.70E+3nMAssay Description:Binding affinity to CK1a1L (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284506(4-[5-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50284506(4-[5-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl...)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibitory activity against 5-lipoxygenase enzyme from RBL-1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Christian-Albrechts University Of Kiel

Curated by ChEMBL
LigandPNGBDBM50284506(4-[5-(4-Fluoro-phenyl)-2-(4-methanesulfonyl-phenyl...)
Affinity DataIC50:  40nMAssay Description:Inhibition of P38betaMAPK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed