BDBM50286773 CHEMBL4174897

SMILES CC(C)C[C@H](N)C(=O)NS(=O)(=O)c1cccc(NC(=S)NC(=O)COc2ccc(Br)cc2Cl)c1

InChI Key InChIKey=CFBBNKTYQXLBCJ-KRWDZBQOSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50286773   

TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Oxford Drug Design

Curated by ChEMBL
LigandPNGBDBM50286773(CHEMBL4174897)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of human cytoplasmic LeuRS assessed as reduction in protein synthesis measured after 10 mins in presence of [3H]Leu by scintillation count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase(Trypanosoma brucei brucei (strain 927/4 GUTat10.1))
Oxford Drug Design

Curated by ChEMBL
LigandPNGBDBM50286773(CHEMBL4174897)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of Trypanosoma brucei LeuRS assessed as reduction in protein synthesis pretreated for 20 mins in presence of [14C]Leu followed by ATP addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed