BDBM50292929 CHEMBL455136::almorexant

SMILES CNC(=O)[C@H](N1CCc2cc(OC)c(OC)cc2[C@@H]1CCc1ccc(cc1)C(F)(F)F)c1ccccc1

InChI Key InChIKey=DKMACHNQISHMDN-RPLLCQBOSA-N

Data  3 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50292929   

TargetOrexin receptor type 2(Homo sapiens (Human))
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50292929(CHEMBL455136 | almorexant)
Affinity DataIC50:  8nMAssay Description:Inhibition of OX2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50292929(CHEMBL455136 | almorexant)
Affinity DataIC50:  8nMAssay Description:Antagonist activity at human OX2R expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50292929(CHEMBL455136 | almorexant)
Affinity DataIC50:  13nMAssay Description:Antagonist activity at human OX1R expressed in CHO cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50292929(CHEMBL455136 | almorexant)
Affinity DataIC50:  13nMAssay Description:Inhibition of OX1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed