BindingDB BDBM50300953 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one::CHEMBL567470

BDBM50300953 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one::CHEMBL567470

SMILES CCCOCCn1c2cc(ncc2nc(N[C@H]2CC[C@H](O)CC2)c1=O)-c1ccc(OC)nc1

InChI Key InChIKey=IVZATIQZZIVIQL-IYARVYRRSA-N

Data 20 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50300953

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50300953(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)

IC50: 64nMAssay Description:Inhibition of PDE11More data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50300953(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)

IC50: 1.21E+3nMAssay Description:Inhibition of PDE4DMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50300953(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)

IC50: 290nMAssay Description:Inhibition of PDE4BMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50300953(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)

IC50: 0.0500nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50300953(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)

IC50: 9.80nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50300953(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)

IC50: >2.00E+3nMAssay Description:Inhibition of PDE1AMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50300953(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)

IC50: >2.00E+3nMAssay Description:Inhibition of PDE1BMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50300953(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)

IC50: >2.00E+3nMAssay Description:Inhibition of PDE1CMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50300953(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)

IC50: >2.00E+3nMAssay Description:Inhibition of PDE2More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50300953(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)

IC50: >2.00E+3nMAssay Description:Inhibition of PDE3AMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50300953(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)

IC50: >2.00E+3nMAssay Description:Inhibition of PDE3BMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50300953(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)

IC50: >2.00E+3nMAssay Description:Inhibition of PDE4AMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50300953(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)

IC50: >2.00E+3nMAssay Description:Inhibition of PDE4CMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50300953(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)

IC50: >2.00E+3nMAssay Description:Inhibition of PDE7AMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50300953(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)

IC50: >2.00E+3nMAssay Description:Inhibition of PDE7BMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50300953(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)

IC50: >2.00E+3nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50300953(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)

IC50: >2.00E+3nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50300953(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)

IC50: >2.00E+3nMAssay Description:Inhibition of PDE9More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50300953(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)

IC50: 290nMAssay Description:Inhibition of PDE4BMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

BDBM50300953(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)

IC50: 0.0500nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Filter my 20 hits

Targets 18▿
- cGMP-specific 3',5'-cyclic phosphodiesterase 2
- cAMP-specific 3',5'-cyclic phosphodiesterase 4B 2
- Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A 1
- High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A 1
- High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B 1
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1
- cGMP-dependent 3',5'-cyclic phosphodiesterase 1
- cAMP-specific 3',5'-cyclic phosphodiesterase 4C 1
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha 1
- cAMP-specific 3',5'-cyclic phosphodiesterase 4D 1
- High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A 1
- cAMP-specific 3',5'-cyclic phosphodiesterase 7B 1
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B 1
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C 1
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 1
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A 1
- cAMP-specific 3',5'-cyclic phosphodiesterase 4A 1
- High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A 1
Publications 2▿
- Bioorg Med Chem Lett 19: 5209-13 (2009) 19
- Bioorg Med Chem Lett 21: 6348-52 (2011) 1
Institutions 1▿
- Pfizer 20
Affinity: 0.050 to 2.0E+3 nM▿
- IC50 20
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 0