BDBM50304148 1H-Indazol-5-ylamine::1H-indazol-5-amine::CHEMBL17551::US9409868, 8::cid_88012

SMILES Nc1ccc2[nH]ncc2c1

InChI Key InChIKey=XBTOSRUBOXQWBO-UHFFFAOYSA-N

Data  6 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50304148   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50304148(1H-Indazol-5-ylamine | 1H-indazol-5-amine | CHEMBL...)
Affinity DataIC50:  1.29E+4nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetProtein RecA(Mycobacterium tuberculosis H37Rv)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50304148(1H-Indazol-5-ylamine | 1H-indazol-5-amine | CHEMBL...)
Affinity DataEC50:  4.86E+4nMAssay Description:Keywords: GFP, refolding, reducing reagent, GFP fluorescence Assay Overview: M. tuberculosis harbors three inteins, which interrupt the DnaB, RecA, a...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetProtein RecA(Mycobacterium tuberculosis H37Rv)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50304148(1H-Indazol-5-ylamine | 1H-indazol-5-amine | CHEMBL...)
Affinity DataEC50:  3.61E+4nMAssay Description:Keywords: GFP-RecA intein, protein splicing, refolding, reducing reagent, GFP fluorescence Assay Overview: M. tuberculosis harbors three inteins, whi...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50304148(1H-Indazol-5-ylamine | 1H-indazol-5-amine | CHEMBL...)
Affinity DataIC50:  1.20E+5nMAssay Description:Inhibition of ROCK2 after 1 hr by FRET-based enzyme-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2 [1-552](Homo sapiens (Human))
H. Lee Moffin Cancer Center and Research Institute

US Patent
LigandPNGBDBM50304148(1H-Indazol-5-ylamine | 1H-indazol-5-amine | CHEMBL...)
Affinity DataIC50:  1.20E+5nMpH: 7.5 T: 2°CAssay Description:A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Uned

Curated by ChEMBL
LigandPNGBDBM50304148(1H-Indazol-5-ylamine | 1H-indazol-5-amine | CHEMBL...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of recombinant NOS1 assessed as citrulline formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute

Curated by ChEMBL
LigandPNGBDBM50304148(1H-Indazol-5-ylamine | 1H-indazol-5-amine | CHEMBL...)
Affinity DataIC50:  1.81E+5nMAssay Description:Inhibition of human His-puritin-tagged ROCK1 expressed in Sf9 cells after 1 hr by FRET-based enzyme-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
H. Lee Moffin Cancer Center and Research Institute

US Patent
LigandPNGBDBM50304148(1H-Indazol-5-ylamine | 1H-indazol-5-amine | CHEMBL...)
Affinity DataIC50:  1.81E+5nMpH: 7.5 T: 2°CAssay Description:A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...More data for this Ligand-Target Pair
In DepthDetails US Patent