BDBM50304355 3,4,6-trichloro-2-(2,5-dichloro-6-hydroxy-3-methylbenzyl)phenol::CHEMBL594863

SMILES Cc1cc(Cl)c(O)c(Cc2c(O)c(Cl)cc(Cl)c2Cl)c1Cl

InChI Key InChIKey=VNYAKMBEQSGVBU-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50304355   

TargetNAD-dependent protein deacetylase HST2(Saccharomyces cerevisiae)
Institute

Curated by ChEMBL
LigandPNGBDBM50304355(3,4,6-trichloro-2-(2,5-dichloro-6-hydroxy-3-methyl...)
Affinity DataKi:  2.50E+3nMAssay Description:Noncompetitive inhibition of yeast Hst2 using NAD+ substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase HST2(Saccharomyces cerevisiae)
Institute

Curated by ChEMBL
LigandPNGBDBM50304355(3,4,6-trichloro-2-(2,5-dichloro-6-hydroxy-3-methyl...)
Affinity DataKi:  2.50E+3nMAssay Description:Mixed inhibition of yeast Hst2 using Acetyl-lysine substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50304355(3,4,6-trichloro-2-(2,5-dichloro-6-hydroxy-3-methyl...)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibition of human full length SIRT1 expressed in DE3 cells by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase HST2(Saccharomyces cerevisiae)
Institute

Curated by ChEMBL
LigandPNGBDBM50304355(3,4,6-trichloro-2-(2,5-dichloro-6-hydroxy-3-methyl...)
Affinity DataIC50:  1.25E+4nMAssay Description:Inhibition of yeast Hst2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed