BDBM50304357 4-(4-ethylphenoxy)-butyric acid 6-oxo-6H-benzo[c]chromen-3-yl ester::CHEMBL595128

SMILES CCc1ccc(OCCCC(O)Oc2ccc3c(c2)oc(=O)c2ccccc32)cc1

InChI Key InChIKey=ZRVNMEZPZXJOIW-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50304357   

TargetNAD-dependent protein deacetylase HST2(Saccharomyces cerevisiae)
Institute

Curated by ChEMBL
LigandPNGBDBM50304357(4-(4-ethylphenoxy)-butyric acid 6-oxo-6H-benzo[c]c...)
Affinity DataKi:  1.20E+3nMAssay Description:Noncompetitive inhibition of yeast Hst2 using NAD+ substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase HST2(Saccharomyces cerevisiae)
Institute

Curated by ChEMBL
LigandPNGBDBM50304357(4-(4-ethylphenoxy)-butyric acid 6-oxo-6H-benzo[c]c...)
Affinity DataKi:  6.30E+3nMAssay Description:Noncompetitive inhibition of yeast Hst2 using Acetyl-lysine substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase HST2(Saccharomyces cerevisiae)
Institute

Curated by ChEMBL
LigandPNGBDBM50304357(4-(4-ethylphenoxy)-butyric acid 6-oxo-6H-benzo[c]c...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of yeast Hst2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50304357(4-(4-ethylphenoxy)-butyric acid 6-oxo-6H-benzo[c]c...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of human full length SIRT1 expressed in DE3 cells by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed