BDBM50306276 CHEMBL595693::phenyl 7-oxo-2,3,7,8,9,9a-hexahydro-1H-benzo[de][1,7]naphthyridine-1-carboxylate

SMILES O=C(Oc1ccccc1)N1CCc2cccc3C(=O)NCC1c23

InChI Key InChIKey=SWAPKPMITWHVKT-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50306276   

TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50306276(CHEMBL595693 | phenyl 7-oxo-2,3,7,8,9,9a-hexahydro...)
Affinity DataEC50:  1.40E+3nMAssay Description:Inhibition of PARP1 in human HeLa cells assessed as inhibition of hydrogen peroxide-induced poly(ADP-ribosyl)ationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50306276(CHEMBL595693 | phenyl 7-oxo-2,3,7,8,9,9a-hexahydro...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed