BDBM50310382 CHEMBL1085161::[4-(2,8-Dihydroxy-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalen-5-yl)phenoxy]acetic AcidMethyl Ester

SMILES COC(=O)COc1ccc(cc1)C1Oc2cc(O)ccc2C2=C1c1ccc(O)cc1OCC2

InChI Key InChIKey=JTNRUVDDTQIJPD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50310382   

TargetEstrogen receptor beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310382(CHEMBL1085161 | [4-(2,8-Dihydroxy-11,12-dihydro-5H...)
Affinity DataIC50:  16nMAssay Description:Inhibition of fluormone ES2 binding to estrogen receptor beta after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310382(CHEMBL1085161 | [4-(2,8-Dihydroxy-11,12-dihydro-5H...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at estrogen receptor in human MCF7 cells assessed as 17beta-estradiol-induced cell proliferation after 24 hrs by [14C]thymidine i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310382(CHEMBL1085161 | [4-(2,8-Dihydroxy-11,12-dihydro-5H...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at estrogen receptor in human Ishikawa cells assessed as 17beta-estradiol-induced alkaline phosphatase activity after 3 days by c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310382(CHEMBL1085161 | [4-(2,8-Dihydroxy-11,12-dihydro-5H...)
Affinity DataIC50:  4.80nMAssay Description:Displacement of radiolabeled estrogen from estrogen receptor alpha by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed