BDBM50312153 1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea::CHEMBL1081198

SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1

InChI Key InChIKey=NWEIPABWNQPRCZ-UHFFFAOYSA-N

Data  26 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 50312153   

TargetProtein kinase C alpha type(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312153(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of PKCalpha after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312153(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Affinity DataIC50:  1.44E+4nMAssay Description:Inhibition of Abl1 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312153(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Affinity DataIC50:  71nMAssay Description:Inhibition of VEGFR3 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312153(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Affinity DataIC50:  62nMAssay Description:Inhibition of EphB4 autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312153(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of ZAp70 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312153(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Affinity DataIC50:  33nMAssay Description:Inhibition of VEGFR2 autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312153(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Affinity DataIC50:  747nMAssay Description:Inhibition of VEGFR1 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312153(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Affinity DataIC50:  67nMAssay Description:Inhibition of Tie2 autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312153(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of Src after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312153(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of Syk after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312153(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of PKCtheta after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312153(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of PKCbeta2 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312153(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Affinity DataIC50:  7.70E+3nMAssay Description:Inhibition of PDGFRbeta after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312153(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of Lyn after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312153(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of LCK after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312153(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of GSK3-beta after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312153(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of Fyn after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312153(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Flt3 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312153(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of FGFR4 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 2(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312153(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Affinity DataIC50:  35nMAssay Description:Inhibition of EPHA2 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312153(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of EGFR after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312153(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of CDK5 after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312153(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Affinity DataIC50:  7.80E+3nMAssay Description:Inhibition of Btk after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312153(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of Blk after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312153(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of Akt after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Cgi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50312153(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of IRK after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed