BDBM50313107 4-chloro-N-cyclopropyl-3-(1-(2,6-difluorophenyl)-1H-pyrazolo[4,3-d]pyridazin-4-ylamino)benzamide::4-chloro-N-cyclopropyl-3-{[1-(2,6-difluorophenyl)-1H-pyrazolo[3,4-d]pyridazin-4-yl]amino}benzamide::CHEMBL1082158

SMILES Fc1cccc(F)c1-n1ncc2c(Nc3cc(ccc3Cl)C(=O)NC3CC3)nncc12

InChI Key InChIKey=ZWVCUFJZBBAOFI-UHFFFAOYSA-N

Data  1 KI  9 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50313107   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-(1-(2,6-difluorophenyl)-1...)
Affinity DataKi:  1nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-(1-(2,6-difluorophenyl)-1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-(1-(2,6-difluorophenyl)-1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of p38betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-(1-(2,6-difluorophenyl)-1...)
Affinity DataIC50: >2.70E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-(1-(2,6-difluorophenyl)-1...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-(1-(2,6-difluorophenyl)-1...)
Affinity DataIC50: >2.70E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-(1-(2,6-difluorophenyl)-1...)
Affinity DataIC50: >2.70E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-(1-(2,6-difluorophenyl)-1...)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
University Of Perugia

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-(1-(2,6-difluorophenyl)-1...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human recombinant p38alpha assessed as phosphorylated ATF2 after 1 hr by HTRF assayMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50313107(4-chloro-N-cyclopropyl-3-(1-(2,6-difluorophenyl)-1...)
Affinity DataIC50: >2.70E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed