BDBM50315678 ((3R,4S)-1-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)((3S,4S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl)methanone::CHEMBL1090484

SMILES CCCCN1C[C@@H]([C@H](C1)c1ccc(F)cc1F)C(=O)N1C[C@H](C)[C@](O)([C@H](C)C1)c1ccccc1

InChI Key InChIKey=ACTXFRVOVCDZTE-CRWYYUFWSA-N

Data  1 KI  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50315678   

TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315678(((3R,4S)-1-butyl-4-(2,4-difluorophenyl)pyrrolidin-...)
Affinity DataKi:  233nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315678(((3R,4S)-1-butyl-4-(2,4-difluorophenyl)pyrrolidin-...)
Affinity DataEC50: >5.72E+3nMAssay Description:Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315678(((3R,4S)-1-butyl-4-(2,4-difluorophenyl)pyrrolidin-...)
Affinity DataEC50:  1.10E+3nMAssay Description:Agonist activity at human recombinant MC1 receptor expressed in HEK293 cells assessed as cAMP accumulation by enzyme fragment complementation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315678(((3R,4S)-1-butyl-4-(2,4-difluorophenyl)pyrrolidin-...)
Affinity DataEC50:  105nMAssay Description:Agonist activity at human recombinant MC4 receptor expressed in CHO cells by cAMP responsive beta lactamase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315678(((3R,4S)-1-butyl-4-(2,4-difluorophenyl)pyrrolidin-...)
Affinity DataEC50:  1.43E+3nMAssay Description:Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed