BDBM50317098 1-(1-{(2S)-3-[(6-chloronaphthalen-2-yl)sulfonyl]-2-hydroxypropanoyl}piperidin-4-yl)tetrahydropyrimidin-2(1H)-one::CHEMBL1095032::TAK-442

SMILES O[C@H](CS(=O)(=O)c1ccc2cc(Cl)ccc2c1)C(=O)N1CCC(CC1)N1CCCNC1=O

InChI Key InChIKey=GEHAEMCVKDPMKO-HXUWFJFHSA-N

Data  1 KI  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50317098   

TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50317098(1-(1-{(2S)-3-[(6-chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317098(1-(1-{(2S)-3-[(6-chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human thrombin after 10 mins by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317098(1-(1-{(2S)-3-[(6-chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of human factor 9a after 10 mins by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317098(1-(1-{(2S)-3-[(6-chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50: >6.00E+4nMAssay Description:Inhibition of human plasmin after 5 mins by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50317098(1-(1-{(2S)-3-[(6-chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human factor 10a using S2222 as substrate after 10 mins by chromogenic assayMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50317098(1-(1-{(2S)-3-[(6-chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50317098(1-(1-{(2S)-3-[(6-chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of human factor 10a assessed as p-nitroanilide release using S2765 as substrate by chromogenic assayMore data for this Ligand-Target Pair
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50317098(1-(1-{(2S)-3-[(6-chloronaphthalen-2-yl)sulfonyl]-2...)
Affinity DataIC50:  4.40E+4nMAssay Description:Inhibition of human tissue plasminogen activator after 5 mins by chromogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed