BDBM50318596 3-((4-(6-Bromo-2-(4-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo-[4,5-b]pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole::CHEMBL1086579

SMILES CN1CCN(CC1)c1nc2ncc(Br)c(N3CCN(Cc4cc(C)on4)CC3)c2[nH]1

InChI Key InChIKey=FZTUPODAEPTYNG-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50318596   

TargetAurora kinase B(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50318596(3-((4-(6-Bromo-2-(4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human recombinant Aurora B expressed in baculovirus systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2A6(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50318596(3-((4-(6-Bromo-2-(4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2A6 from human liver microsome by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50318596(3-((4-(6-Bromo-2-(4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human recombinant Aurora C expressed in baculovirus systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50318596(3-((4-(6-Bromo-2-(4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2 from human liver microsome by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50318596(3-((4-(6-Bromo-2-(4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant Aurora A expressed in baculovirus systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50318596(3-((4-(6-Bromo-2-(4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19 from human liver microsome by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50318596(3-((4-(6-Bromo-2-(4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 from human liver microsome by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50318596(3-((4-(6-Bromo-2-(4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 from human liver microsome by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50318596(3-((4-(6-Bromo-2-(4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50318596(3-((4-(6-Bromo-2-(4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 from human liver microsome by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed