BDBM50320203 CHEMBL1085511::isobutyl4-(7-amino-3-(4-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenylcarbamate

SMILES CC(C)COC(=O)Nc1ccc(cc1)-c1cnc2c(cnn2c1N)-c1ccc(cc1)N1CCN(C)CC1

InChI Key InChIKey=DAZCBQNFGSWSQG-UHFFFAOYSA-N

Data  25 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50320203   

TargetTyrosine-protein kinase Lck(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320203(isobutyl4-(7-amino-3-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 22nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320203(isobutyl4-(7-amino-3-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 40nMAssay Description:Inhibition of ABLMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320203(isobutyl4-(7-amino-3-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 74nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320203(isobutyl4-(7-amino-3-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 89nMAssay Description:Inhibition of cKItMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320203(isobutyl4-(7-amino-3-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 107nMAssay Description:Inhibition of LCK in human Jurkat cells assessed as ZAP70 phosphorylation by FACS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320203(isobutyl4-(7-amino-3-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 181nMAssay Description:Inhibition of HCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320203(isobutyl4-(7-amino-3-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 662nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320203(isobutyl4-(7-amino-3-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of tie2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320203(isobutyl4-(7-amino-3-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 4.23E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320203(isobutyl4-(7-amino-3-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of RetMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320203(isobutyl4-(7-amino-3-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320203(isobutyl4-(7-amino-3-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320203(isobutyl4-(7-amino-3-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Her2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320203(isobutyl4-(7-amino-3-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320203(isobutyl4-(7-amino-3-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320203(isobutyl4-(7-amino-3-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of INSRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320203(isobutyl4-(7-amino-3-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR3KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320203(isobutyl4-(7-amino-3-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of cMetMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320203(isobutyl4-(7-amino-3-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AlkMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320203(isobutyl4-(7-amino-3-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKBalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320203(isobutyl4-(7-amino-3-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320203(isobutyl4-(7-amino-3-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Her1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320203(isobutyl4-(7-amino-3-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK2/cyclinAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320203(isobutyl4-(7-amino-3-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ZAP70More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetLysine--tRNA ligase(Human)
Novartis Institute of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50320203(isobutyl4-(7-amino-3-(4-(4-methylpiperazin-1-yl)ph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SykMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed