BDBM50326659 3,10-dimethoxy-17-methyl-(10S)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-13-one::3,10-dimethoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-13-one::CHEMBL606644

SMILES COc1cccc2C[C@H]3N(C)CC[C@@]4(CC(=O)CC[C@@]34OC)c12

InChI Key InChIKey=FXPIRWWMNVRGSD-BHIYHBOVSA-N

Data  6 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50326659   

TargetMu-type opioid receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50326659(3,10-dimethoxy-17-methyl-(10S)-17-azatetracyclo[7....)
Affinity DataKi:  0.700nMAssay Description:Binding affinity by its ability to displace [3H]DAMGO from mu receptor in homogenates of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Innsbruck And Center For Molecular Biosciences Innsbruck-Cmbi

Curated by ChEMBL
LigandPNGBDBM50326659(3,10-dimethoxy-17-methyl-(10S)-17-azatetracyclo[7....)
Affinity DataKi:  1.15nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
TBA

Curated by ChEMBL
LigandPNGBDBM50326659(3,10-dimethoxy-17-methyl-(10S)-17-azatetracyclo[7....)
Affinity DataKi:  1.5nMAssay Description:Binding affinity by its ability to displace [3H]-U-69,593 from kappa receptor in homogenates of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDelta-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50326659(3,10-dimethoxy-17-methyl-(10S)-17-azatetracyclo[7....)
Affinity DataKi:  46nMAssay Description:Binding affinity by its ability to displace [3H]DPDPE from delta receptor in homogenates of guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
University Of Innsbruck And Center For Molecular Biosciences Innsbruck-Cmbi

Curated by ChEMBL
LigandPNGBDBM50326659(3,10-dimethoxy-17-methyl-(10S)-17-azatetracyclo[7....)
Affinity DataKi:  101nMAssay Description:Displacement of [3H][Ile5,6]deltorphin2 from delta opioid receptor in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
TBA

Curated by ChEMBL
LigandPNGBDBM50326659(3,10-dimethoxy-17-methyl-(10S)-17-azatetracyclo[7....)
Affinity DataKi:  403nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
University Of Innsbruck And Center For Molecular Biosciences Innsbruck-Cmbi

Curated by ChEMBL
LigandPNGBDBM50326659(3,10-dimethoxy-17-methyl-(10S)-17-azatetracyclo[7....)
Affinity DataIC50:  4.62E+4nMAssay Description:Inhibition of electric eel AChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50326659(3,10-dimethoxy-17-methyl-(10S)-17-azatetracyclo[7....)
Affinity DataIC50:  3.5nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the presence of NaClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50326659(3,10-dimethoxy-17-methyl-(10S)-17-azatetracyclo[7....)
Affinity DataIC50:  0.300nMAssay Description:Concentration for 50% inhibition of [3H]naloxone (1 M) binding to opioid receptor in rat brain membrane was determined in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed