BDBM50326709 (R)-1-(2-oxo-5-phenethyl-1-propyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-3-(4-(4-(pyridin-4-yl)piperazin-1-yl)phenyl)urea::CHEMBL1253497

SMILES CCCN1c2ccccc2C(CCc2ccccc2)=N[C@@H](NC(=O)Nc2ccc(cc2)N2CCN(CC2)c2ccncc2)C1=O

InChI Key InChIKey=VLIFIGMDNURHMV-UMSFTDKQSA-N

Data  4 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50326709   

TargetB1 bradykinin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50326709((R)-1-(2-oxo-5-phenethyl-1-propyl-2,3-dihydro-1H-b...)
Affinity DataKi:  0.590nMAssay Description:Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50326709((R)-1-(2-oxo-5-phenethyl-1-propyl-2,3-dihydro-1H-b...)
Affinity DataKi:  0.590nMAssay Description:Inhibition of human bradykinin B1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(RAT)
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50326709((R)-1-(2-oxo-5-phenethyl-1-propyl-2,3-dihydro-1H-b...)
Affinity DataKi:  0.920nMAssay Description:Binding affinity to rat bradykinin B1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(RAT)
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50326709((R)-1-(2-oxo-5-phenethyl-1-propyl-2,3-dihydro-1H-b...)
Affinity DataKi:  0.920nMAssay Description:Compound was tested for inhibition against rat Bradykinin receptor B1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50326709((R)-1-(2-oxo-5-phenethyl-1-propyl-2,3-dihydro-1H-b...)
Affinity DataIC50:  1.90nMAssay Description:Antagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50326709((R)-1-(2-oxo-5-phenethyl-1-propyl-2,3-dihydro-1H-b...)
Affinity DataIC50:  1.90nMAssay Description:Compound was tested for inhibition against human bradykinin B1 receptor using FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(RAT)
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50326709((R)-1-(2-oxo-5-phenethyl-1-propyl-2,3-dihydro-1H-b...)
Affinity DataIC50:  2.80nMAssay Description:Compound was tested for inhibition against rat Bradykinin receptor B1 using FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(RAT)
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50326709((R)-1-(2-oxo-5-phenethyl-1-propyl-2,3-dihydro-1H-b...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of rat bradykinin B1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed