BDBM50328188 CHEMBL1257540::US9670214, TABLE 13.11::piperazin-1-yl(4-(4-(trifluoromethoxy)phenylamino)thieno[2,3-d]pyrimidin-6-yl)methanone

SMILES FC(F)(F)Oc1ccc(Nc2ncnc3sc(cc23)C(=O)N2CCNCC2)cc1

InChI Key InChIKey=JCSDWWOAIWNEQV-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50328188   

TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50328188(CHEMBL1257540 | US9670214, TABLE 13.11 | piperazin...)
Affinity DataEC50:  406nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-specific protein-tyrosine kinase [T818I](Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50328188(CHEMBL1257540 | US9670214, TABLE 13.11 | piperazin...)
Affinity DataIC50:  2.30E+3nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNon-specific protein-tyrosine kinase(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50328188(CHEMBL1257540 | US9670214, TABLE 13.11 | piperazin...)
Affinity DataIC50:  406nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In DepthDetails US Patent