BDBM50328192 CHEMBL1257781::N-(4-(Trifluoromethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine::US9670214, TABLE 12.2

SMILES FC(F)(F)Oc1ccc(Nc2ncnc3[nH]ccc23)cc1

InChI Key InChIKey=JIHDZQXFAZNODD-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50328192   

TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50328192(CHEMBL1257781 | N-(4-(Trifluoromethoxy)phenyl)-7H-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of Bcr-Abl in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-specific protein-tyrosine kinase(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50328192(CHEMBL1257781 | N-(4-(Trifluoromethoxy)phenyl)-7H-...)
Affinity DataIC50: >1.00E+4nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTau-tubulin kinase 2(Homo sapiens (Human))
Csic

Curated by ChEMBL
LigandPNGBDBM50328192(CHEMBL1257781 | N-(4-(Trifluoromethoxy)phenyl)-7H-...)
Affinity DataIC50:  8.80E+3nMAssay Description:Inhibition of recombinant human TTBK2 using RICDLHDDEEDEAMSITA as substrate incubated for 30 mins in presence of 33P-gamma-ATPMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTau-tubulin kinase 1(Homo sapiens (Human))
Csic

Curated by ChEMBL
LigandPNGBDBM50328192(CHEMBL1257781 | N-(4-(Trifluoromethoxy)phenyl)-7H-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of recombinant human TTBK1 using RICDLHDDEEDEAMSITA as substrate incubated for 30 mins in presence of 33P-gamma-ATPMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNon-specific protein-tyrosine kinase [T818I](Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50328192(CHEMBL1257781 | N-(4-(Trifluoromethoxy)phenyl)-7H-...)
Affinity DataIC50: >1.00E+4nMpH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In DepthDetails US Patent