BDBM50329102 CHEMBL364613::Indole alkaloid derivative::coronaridine

SMILES CC[C@H]1C[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@](C2)([C@H]13)C(=O)OC

InChI Key InChIKey=NVVDQMVGALBDGE-KSWFMABOSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50329102   

TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50329102(CHEMBL364613 | Indole alkaloid derivative | corona...)
Affinity DataEC50:  1.60E+4nMAssay Description:Agonist activity at human TRPA1 expressed in T-REx HEK cells assessed as increase in intracellular Ca2+ accumulation by Fluo-4 AM dye based fluoresce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50329102(CHEMBL364613 | Indole alkaloid derivative | corona...)
Affinity DataIC50:  1.70E+5nMAssay Description:Antagonist activity against human TRPV1 expressed in T-REx HEK cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ accum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50329102(CHEMBL364613 | Indole alkaloid derivative | corona...)
Affinity DataIC50:  8.60E+3nMAssay Description:Inhibition of electric eel AChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Mus musculus)
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50329102(CHEMBL364613 | Indole alkaloid derivative | corona...)
Affinity DataIC50:  3.00E+3nMAssay Description:Antagonist activity against mouse TRPM8 expressed in T-REx HEK cells assessed as inhibition of menthol-induced increase in intracellular Ca2+ accumul...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Mus musculus)
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50329102(CHEMBL364613 | Indole alkaloid derivative | corona...)
Affinity DataIC50:  1.60E+4nMAssay Description:Antagonist activity against mouse TRPM8 expressed in T-REx HEK cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ accumula...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed