BDBM50330290 CHEMBL1272326::Cyclohexyl-[4-(3-isopropyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-amine

SMILES CC(C)c1[nH]ncc1-c1ccnc(NC2CCCCC2)n1

InChI Key InChIKey=LOYSCNBYDPTSAA-UHFFFAOYSA-N

Data  4 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50330290   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50330290(CHEMBL1272326 | Cyclohexyl-[4-(3-isopropyl-1H-pyra...)
Affinity DataKi:  18nMAssay Description:Inhibition of human full length GST-tagged CDK4 (1 to 303(end) amino acids)/Cyclin D3 (1 to 292(end) amino acids) expressed in baculovirus expression...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50330290(CHEMBL1272326 | Cyclohexyl-[4-(3-isopropyl-1H-pyra...)
Affinity DataKi:  22nMAssay Description:Inhibition of human full length GST-tagged CDK2 (1 to 298(end) amino acids)/Cyclin E1 (1 to 410(end) amino acids) expressed in baculovirus expression...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50330290(CHEMBL1272326 | Cyclohexyl-[4-(3-isopropyl-1H-pyra...)
Affinity DataKi:  24nMAssay Description:Inhibition of human recombinant full length GST-tagged CDK1/Cyclin A2 expressed in sf9 insect cells assessed as inhibition constant using Ulight-4E-B...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50330290(CHEMBL1272326 | Cyclohexyl-[4-(3-isopropyl-1H-pyra...)
Affinity DataKi:  450nMAssay Description:Inhibition of human full length GST-tagged CDK6 (1 to 326(end) amino acids)/Cyclin D3 (1 to 292(end) amino acids) expressed in baculovirus expression...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed