BDBM50334150 1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one::1-(1-{3-[Bis-(4-fluoro-phenyl)-amino]-propyl}-piperidin-4-yl)-1,3-dihydro-benzoimidazol-2-one::1-(1-{3-[Bis-(4-fluoro-phenyl)-amino]-propyl}-piperidin-4-yl)-1,3-dihydro-benzoimidazol-2-one(Pimozide)::1-{1-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one::1-{1-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one(Pimozide)::CHEMBL1423::MCN-JR-6238::N-benzyl-N-(3-isobutoxy-2-(pyrrolidin-1-yl)propyl)benzenamine::NCGC00015802::Orap::PIMOZIDE1-{1-[4,4-BIS-(4-FLUORO-PHENYL)-BUTYL]-PIPERIDIN-4-YL}-1,3-DIHYDRO-BENZOIMIDAZOL-2-ONE::Pimozide::R-6238

SMILES Fc1ccc(cc1)C(CCCN1CCC(CC1)n1c2ccccc2[nH]c1=O)c1ccc(F)cc1

InChI Key InChIKey=YVUQSNJEYSNKRX-UHFFFAOYSA-N

Data  82 KI  43 IC50  1 Kd  2 EC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 43 hits for monomerid = 50334150   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  55.0nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetArachidonate 15-lipoxygenase(Pseudomonas aeruginosa)
University of California Santa Cruz

LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  5.80E+3nMT: 2°CAssay Description:Briefly, 3 uL of enzyme (approximately 20 nM LoxA, final concentration) or buffer (no-enzyme control) was dispensed into 1536-well Greiner black clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  3.76E+3nMAssay Description:Binding affinity against delta opiate receptor using [3H]DPDPEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of USP1 (unknown origin) assessed as reduction in K63-linked diUb cleavage by gel electrophoresis based orthogonal diUb cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  54nMAssay Description:Inhibition of Na channel (species unknown)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  162nMAssay Description:Inhibition of voltage-gated L-type Ca channel (species unknown)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  20nMAssay Description:Inhibition of hERG K channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCytochrome P450 2J2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2J2 in human liver microsomes using 7 probe cocktail containing phenacetin, paclitaxel, diclofenac, S-mephenytoin, dextromethorphan,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2J2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2J2-mediated astemizole O-demethylation in human liver microsomes after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCytochrome P450 2C9(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPotassium channel subfamily K member 2(Homo sapiens (Human))
Korea Institute of Science and Technology

LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of of human TREK1 expressed in whole COS cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  18nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human Potassium channel HERG expressed in mammalian cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity against Potassium channel HERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMu-type opioid receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  372nMAssay Description:Binding affinity against mu opioid receptor using [3H]DAMGOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  990nMAssay Description:Binding affinity against opioid receptor kappa 1 by using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  18nMAssay Description:K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetATP-dependent translocase ABCB1(Mus musculus (Mouse))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  9.70E+3nMAssay Description:Inhibition of human cytochrome P450 3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetATP-dependent translocase ABCB1(Mus musculus)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  800nMAssay Description:Inhibition of P-glycoprotein using calcein-AM assay transfected in porcine PBCECMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibitory concentration against IKr potassium channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetWD repeat-containing protein 48(Homo sapiens (Human))
University Of Connecticut Health Center

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human USP1/UAF1 complex using Ub-Rho as substrate by qHTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open stateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMultidrug and toxin extrusion protein 2(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug and toxin extrusion protein 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 2(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  3.42E+4nMAssay Description:Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  54.6nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  18.2nMAssay Description:Inhibition of human ERG in MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  50.1nMAssay Description:Inhibitory concentration against potassium channel HERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  50.1nMAssay Description:Inhibition of human ERG expressed in CHO cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  3.02nMAssay Description:Inhibition of human ERG channel in HEK293 cells by voltage-clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  2.90E+3nMAssay Description:TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of [3H]haloperidol binding to dopamine receptors in rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of [3H]haloperidol binding to dopamine receptors in rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  240nMAssay Description:Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed