BDBM50334594 2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)pyrimidin-4-ylamino)-N-methylbenzamide::2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDE::2-[5-chloro-2-[2-methoxy-4-(4-morpholinyl)phenylamino]pyrimidin-4-ylamino]-N-methylbenzamide::CHEMBL458997::TAE226::US10266549, Example 12::US10774092, Example 12
SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCOCC2)ncc1Cl
InChI Key InChIKey=UYJNQQDJUOUFQJ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 33 hits for monomerid = 50334594
Affinity DataIC50: 7nMAssay Description:Inhibition of pre-activated recombinant full length FAK (unknown origin) using ULight labeled poly(Glu/Tyr) as substrate after 1.6 hrs by TR-FRET ass...More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:Inhibition of recombinant FAK domain (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of ALK by cell based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of insulin receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant insulin receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of FAK (unknown origin) using ULight-poly GT as substrate after 1.6 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of human AURKAMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of FAK (unknown origin) using Ulight-poly(Glu:Tyr)(4:1) as substrate after 1.6 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.80nMAssay Description:Inhibition of recombinant human N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 Gl...More data for this Ligand-Target Pair
Affinity DataIC50: <200nMAssay Description:Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...More data for this Ligand-Target Pair
Affinity DataIC50: 6.80nMAssay Description:Inhibition of recombinant human N-terminal His-tagged FAK cytoplasmic domain (393 to 698 residues) expressed in baculovirus infected sf9 cells assess...More data for this Ligand-Target Pair
Affinity DataIC50: 6.20nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human FAK (327 to 1052 residues) expressed in baculovirus expression system using TK as substrate inc...More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6.80nMAssay Description:Inhibition of human recombinant N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 Gl...More data for this Ligand-Target Pair
Affinity DataIC50: <200nMAssay Description:ULK1 inhibition assay is a screening assay to identify compounds that inhibit kinase activity of ULK1 using the ULKtide peptide. In some embodiments,...More data for this Ligand-Target Pair
Affinity DataIC50: 6.30nMAssay Description:Inhibition of N-terminal GST-fused human truncated FAK (376 to 1052 residues) expressed in baculovirus expression system using tyrosine kinase peptid...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Dana-Farber Cancer Institute
Curated by ChEMBL
Dana-Farber Cancer Institute
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:Inhibition of Focal adhesion kinase (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of GST-tagged recombinant PDGFRbeta (unknown origin) expressed in baculovirus expression system incubated for 15-45 mins in presence of [g...More data for this Ligand-Target Pair
Affinity DataIC50: 710nMAssay Description:Inhibition of GST-tagged recombinant HER2 (unknown origin) expressed in baculovirus expression system incubated for 15-45 mins in presence of [gamma3...More data for this Ligand-Target Pair
Affinity DataIC50: 550nMAssay Description:Inhibition of GST-tagged recombinant HER1 (unknown origin) expressed in baculovirus expression system incubated for 15-45 mins in presence of [gamma3...More data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:Inhibition of GST-tagged recombinant INSR (unknown origin) expressed in baculovirus expression system incubated for 15-45 mins in presence of [gamma3...More data for this Ligand-Target Pair
Affinity DataIC50: 750nMAssay Description:Inhibition of GST-tagged recombinant FGFR1 (unknown origin) expressed in baculovirus expression system incubated for 15-45 mins in presence of [gamma...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Dana-Farber Cancer Institute
Curated by ChEMBL
Dana-Farber Cancer Institute
Curated by ChEMBL
Affinity DataIC50: 81nMAssay Description:Inhibition of GST-tagged recombinant IGFR1 (unknown origin) expressed in baculovirus expression system incubated for 15-45 mins in presence of [gamma...More data for this Ligand-Target Pair
Affinity DataIC50: 5.40nMAssay Description:Inhibition of GST-tagged recombinant FAK (unknown origin) expressed in baculovirus expression system incubated for 15-45 mins in presence of [gamma32...More data for this Ligand-Target Pair
Affinity DataIC50: 5.80nMAssay Description:Inhibition of recombinant human N-terminal His-tagged FAK (393 to 698 residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 Gl...More data for this Ligand-Target Pair
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of FAK (unknown origin) by FRET-based Z'-Lyte assayMore data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of human recombinant full length FAK incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting metho...More data for this Ligand-Target Pair
Affinity DataIC50: 4.5nMAssay Description:Inhibition of recombinant human FAK (393 to 698 residues) using poly (4:1 Glu, Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.90nMAssay Description:Inhibition of N-terminal DYKDDDD-tagged truncated FAK (376 to 1052 residues) (unknown origin) expressed in Sf21 insect cells using TK as substrate in...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1 [547-977](Homo sapiens (Human))
University of Washington
University of Washington
Affinity DataIC50: 860nMpH: 7.5Assay Description:Inhibitors (initial concentration 10 or 60 μM, three-fold serial dilutions) were incubated with IRE1α* in cleavage buffer (20 mM HEPES at p...More data for this Ligand-Target Pair