BDBM50335188 CHEMBL1650545::CHEMBL1650551::N-[3-[(3,3-Difluoro-1-pyrrolidinyl)methyl]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Hydrochloride

SMILES Cc1cn2c(cnc2c(Nc2cc(CN3CCC(F)(F)C3)ns2)n1)-c1cn[nH]c1

InChI Key InChIKey=JVAFTPDILUBIGR-UHFFFAOYSA-N

Data  48 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 48 hits for monomerid = 50335188   

TargetAurora kinase B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50:  63nMAssay Description:Inhibition of Aurora B in human HCT116 cells assessed as inhibition of histone H3 phosphorylation by immunofluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50:  200nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of PKCAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of PKCAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of PLK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of RSK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of IKK-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50:  91nMAssay Description:Inhibition of Aurora B in human HCT116 cells assessed as inhibition of histone H3 phosphorylation by immunofluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTestis-specific serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of TSSK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50:  640nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type IV(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of CAMK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50:  770nMAssay Description:Inhibition of EPHB4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of METMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50:  76nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of CSNK1DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of NEK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50:  2.35E+3nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50:  550nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50:  700nMAssay Description:Inhibition of EPHB4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50:  46nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50:  640nMAssay Description:Inhibition of IRAK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50:  340nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50:  470nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type IV(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of CAMK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of MST2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of PLK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of RSK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTestis-specific serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of TSSK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of CSNK1DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of IKK-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of METMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of NEK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50335188(CHEMBL1650545 | CHEMBL1650551 | N-[3-[(3,3-Difluor...)
Affinity DataIC50: >100nMAssay Description:Inhibition of MST2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed