BDBM50336962 2,3,4,5-Tetrahydro-10-hydroxybenzo[b]thieno[2,3-f]-1,5-thiazocin-6-one::CHEMBL1672573::kb-NB165-92

SMILES Oc1ccc2sc3c(SCCCNC3=O)c2c1

InChI Key InChIKey=ZUYALLZMSFUHFE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50336962   

TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336962(2,3,4,5-Tetrahydro-10-hydroxybenzo[b]thieno[2,3-f]...)
Affinity DataIC50:  111nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D2(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336962(2,3,4,5-Tetrahydro-10-hydroxybenzo[b]thieno[2,3-f]...)
Affinity DataIC50:  101nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336962(2,3,4,5-Tetrahydro-10-hydroxybenzo[b]thieno[2,3-f]...)
Affinity DataIC50:  111nMAssay Description:Inhibition of human recombinant PKD1 after 10 mins by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336962(2,3,4,5-Tetrahydro-10-hydroxybenzo[b]thieno[2,3-f]...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of PKD1 autophosphorylation at Ser916 in human PMA-induced LNCAP cells by Western blottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D3(Homo sapiens (Human))
University of Pittsburgh

LigandPNGBDBM50336962(2,3,4,5-Tetrahydro-10-hydroxybenzo[b]thieno[2,3-f]...)
Affinity DataIC50:  58.8nMpH: 7.5 T: 2°CAssay Description:In vitro radiometric kinase assay were conducted using PKD1 from Biomol International, PKD2 from SignalChem and PKD3 Enzo Life Sciences.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed