BDBM50339372 (+/-)-4-((1-(4-Chlorophenyl)-1-((1-(hydroxymethyl)cyclopropyl)methoxy)-3-oxoisoindolin-2-yl)methyl)benzonitrile::CHEMBL1688277::US8618158, NU8415

SMILES OCC1(COC2(N(Cc3ccc(cc3)C#N)C(=O)c3ccccc23)c2ccc(Cl)cc2)CC1

InChI Key InChIKey=MLERFWCEHUYEDZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50339372   

TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50339372((+/-)-4-((1-(4-Chlorophenyl)-1-((1-(hydroxymethyl)...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of Mdm2 -p53 protein interaction by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50339372((+/-)-4-((1-(4-Chlorophenyl)-1-((1-(hydroxymethyl)...)
Affinity DataIC50:  1.79E+3nMT: 2°CAssay Description:Streptavidin-coated 96-well plates are used to immobilise a biotin-tagged IP3 p53-derived peptide (MPRFMDYWEGLN). This is a peptide analogue derived ...More data for this Ligand-Target Pair
In DepthDetails US Patent