BDBM50339607 1-Hydroxy-6-phenyl-4-trifluoromethyl-1H-indole-2-carboxylic Acid::CHEMBL1688790::LDHA Inhibitor, 4

SMILES OC(=O)c1cc2c(cc(cc2n1O)-c1ccccc1)C(F)(F)F

InChI Key InChIKey=KGXDBNBXAPVUIM-UHFFFAOYSA-N

Data  2 KI  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50339607   

TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Universita` Di Pisa

Curated by ChEMBL
LigandPNGBDBM50339607(1-Hydroxy-6-phenyl-4-trifluoromethyl-1H-indole-2-c...)
Affinity DataKi:  4.70E+3nMAssay Description:Competitive inhibition of human LDH-A using pyruvate as substrate after 5 mins by calorimetric assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Universita` Di Pisa

Curated by ChEMBL
LigandPNGBDBM50339607(1-Hydroxy-6-phenyl-4-trifluoromethyl-1H-indole-2-c...)
Affinity DataKi:  8.90E+3nMAssay Description:Competitive inhibition of human LDH-A using NADH as substrate after 5 mins by calorimetric assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Universita` Di Pisa

Curated by ChEMBL
LigandPNGBDBM50339607(1-Hydroxy-6-phenyl-4-trifluoromethyl-1H-indole-2-c...)
Affinity DataIC50: >5.00E+5nMpH: 7.5 T: 2°CAssay Description:Enzyme assay using lactate dehydrogenase A (LDHA).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Universita` Di Pisa

Curated by ChEMBL
LigandPNGBDBM50339607(1-Hydroxy-6-phenyl-4-trifluoromethyl-1H-indole-2-c...)
Affinity DataKd:  9.00E+3nMpH: 7.5 T: 2°CAssay Description:NMR spectra were acquired on Bruker Avance 600 MHz spectrometers at 298 K using a 5 mm triple-resonance HCN cryoprobe. Ligand binding was detected u...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed