BDBM50340530 (S)-1-(4-methoxybenzyl)-5-(2-((pyridin-3-yloxy)methyl)azetidin-1-ylsulfonyl)indoline-2,3-dione::CHEMBL1762350

SMILES COc1ccc(CN2C(=O)C(=O)c3cc(ccc23)S(=O)(=O)N2CC[C@H]2COc2cccnc2)cc1

InChI Key InChIKey=YDPWIEQYFRHMKK-SFHVURJKSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50340530   

TargetCaspase-1(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50340530((S)-1-(4-methoxybenzyl)-5-(2-((pyridin-3-yloxy)met...)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of caspase 1 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50340530((S)-1-(4-methoxybenzyl)-5-(2-((pyridin-3-yloxy)met...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of human caspase 3 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50340530((S)-1-(4-methoxybenzyl)-5-(2-((pyridin-3-yloxy)met...)
Affinity DataEC50:  450nMAssay Description:Inhibition of staurosporine induced activation of caspase 3 activation in human Hela cells assessed as hydrolysis of Z-DEVD-R110 substrate by micropl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50340530((S)-1-(4-methoxybenzyl)-5-(2-((pyridin-3-yloxy)met...)
Affinity DataIC50:  10.2nMAssay Description:Inhibition of caspase 7 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50340530((S)-1-(4-methoxybenzyl)-5-(2-((pyridin-3-yloxy)met...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of caspase 8 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50340530((S)-1-(4-methoxybenzyl)-5-(2-((pyridin-3-yloxy)met...)
Affinity DataIC50:  9.20E+3nMAssay Description:Inhibition of caspase 6 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed