BDBM50340754 (S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluorobenzylamino)-N-hydroxyhexanamide::CHEMBL1760324

SMILES Cc1cc(C[C@H](CCCCNCc2ccc(F)cc2)C(=O)NO)cc(C)c1F

InChI Key InChIKey=PVPXSRWESCVIBD-IBGZPJMESA-N

Data  7 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50340754   

TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340754((S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoroben...)
Affinity DataKi:  0.130nMAssay Description:Inhibition of Bacillus anthracis lethal factor assessed as proteolysis using MCA-KKVYPYPME-Dap(Dnp)-NH2 peptide substrate after 4 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340754((S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoroben...)
Affinity DataKi:  0.130nMAssay Description:Inhibition of N-terminal 6-histine tagged Bacillus anthracis LF 263-C terminal catalytic domain using MCA-KKVYPYPME-Dap(Dnp)-NH2 as substrate after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340754((S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoroben...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of MMP-9 using OmniMMP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340754((S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoroben...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of MMP-1 using OmniMMP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340754((S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoroben...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of MMP-12 using OmniMMP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340754((S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoroben...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of MMP-14 using OmniMMP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340754((S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoroben...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of MMP-3 using OmniMMP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340754((S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoroben...)
Affinity DataIC50:  4.65E+3nMAssay Description:Inhibition of human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Panthera Biopharma

Curated by ChEMBL
LigandPNGBDBM50340754((S)-2-(4-fluoro-3,5-dimethylbenzyl)-6-(4-fluoroben...)
Affinity DataIC50:  20nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed