BDBM50341816 (1S,2R,3R)-1-[5-(4-Methoxypyrazol-1-yl)thiophene-2-sulfonylamino]-2-methyl-3-phenylcyclopropanecarboxylic Acid::CHEMBL1766899

SMILES COc1cnn(c1)-c1ccc(s1)S(=O)(=O)N[C@]1([C@H](C)[C@@H]1c1ccccc1)C(O)=O

InChI Key InChIKey=DSLRBIQFKOUGKT-LLSQANQASA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50341816   

TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50341816((1S,2R,3R)-1-[5-(4-Methoxypyrazol-1-yl)thiophene-2...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human recombinant MMP14 after 60 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50341816((1S,2R,3R)-1-[5-(4-Methoxypyrazol-1-yl)thiophene-2...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of human recombinant TACE after 60 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50341816((1S,2R,3R)-1-[5-(4-Methoxypyrazol-1-yl)thiophene-2...)
Affinity DataIC50:  33nMAssay Description:Inhibition of human recombinant MMP1 after 60 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50341816((1S,2R,3R)-1-[5-(4-Methoxypyrazol-1-yl)thiophene-2...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human recombinant aggrecanase 2 after 150 mins by fluorescence plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed