BDBM50343431 1-(2-Chloro-2-phenylethyl)-6-[(2-morpholin-4-ylethyl)thio]-Nphenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine::CHEMBL1775035

SMILES ClC(Cn1ncc2c(Nc3ccccc3)nc(SCCN3CCOCC3)nc12)c1ccccc1

InChI Key InChIKey=VXPRLPJXOGZRAZ-UHFFFAOYSA-N

Data  8 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50343431   

TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50343431(1-(2-Chloro-2-phenylethyl)-6-[(2-morpholin-4-yleth...)
Affinity DataKi:  150nMAssay Description:Inhibition of human recombinant c-Abl by filter-binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50343431(1-(2-Chloro-2-phenylethyl)-6-[(2-morpholin-4-yleth...)
Affinity DataKi:  150nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50343431(1-(2-Chloro-2-phenylethyl)-6-[(2-morpholin-4-yleth...)
Affinity DataKi:  210nMAssay Description:Inhibition of c-SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50343431(1-(2-Chloro-2-phenylethyl)-6-[(2-morpholin-4-yleth...)
Affinity DataKi:  210nMAssay Description:Inhibition of c-src kinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50343431(1-(2-Chloro-2-phenylethyl)-6-[(2-morpholin-4-yleth...)
Affinity DataKi:  210nMAssay Description:Inhibition of human recombinant c-Src by filter-binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50343431(1-(2-Chloro-2-phenylethyl)-6-[(2-morpholin-4-yleth...)
Affinity DataKi:  220nMAssay Description:Inhibition of human recombinant Abl kinase using [gamma-32P]ATP as substrate by filter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50343431(1-(2-Chloro-2-phenylethyl)-6-[(2-morpholin-4-yleth...)
Affinity DataKi:  240nMAssay Description:Inhibition of human recombinant src kinase using KVEKIGEGTYGVVYK as substrate by filter binding assay in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50343431(1-(2-Chloro-2-phenylethyl)-6-[(2-morpholin-4-yleth...)
Affinity DataKi:  7.50E+3nMAssay Description:Inhibition of human recombinant full-length Fyn using Src substrate peptide after 15 mins incubation by MicroBeta liquid scintillation counting analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed