BDBM50343559 1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-2-(TRIFLUOROMETHOXY)PHENYL]AMINO]-4,5-DIHYDROPYRIMIDO[5,4-G]INDAZOLE-3-CARBOXAMIDE::1-(2-hydroxyethyl)-8-(5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1738758

SMILES CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(CCO)c4-c3n2)C(N)=O)c1

InChI Key InChIKey=QHLVBNKYJGBCQJ-UHFFFAOYSA-N

Data  61 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 119 hits for monomerid = 50343559   

LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 0.00200nMAssay Description:Inhibition of PLK1 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 0.510nMAssay Description:Inhibition of FLT3 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 0.744nMAssay Description:Inhibition of MELK (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 0.826nMAssay Description:Inhibition of CK2 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to PLK1 (unknown origin) assessed as inhibition constant incubated for 180 mins in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of PLK1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of PLK1 (unknown origin) by ATP competitive assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details Article
PubMed
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 3nMpH: 7.9Assay Description:The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2015
Entry Details
US Patent

LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of ROS (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of RET (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of PKC beta (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of PIM2 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of TYK2 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of TRKA (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of TLK2 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of SYK (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of ZAP70 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of VEGFR3 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of VEGFR2 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of PLK3 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of PLK2 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of AKT1 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetActivated CDC42 kinase 1(Human)TBA
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of ACK1 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of ABL (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDC7/DBF4 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of BUB1 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of BRK (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of ALK (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK1/CycB (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of LYN (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of LCK (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of KIT (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of JAK3 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of MPS1 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of MNK2 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of MET (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of MAPKAPK2 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of P38alpha (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of NIM1 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of NEK6 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of MST4 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of PIM1 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of PERK (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of PDK1 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of PAK4 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CHK1 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK5/P25 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK4/CycD1 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK2/CycE (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50343559(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of ERK2 (unknown origin) in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
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