BDBM50343726 (S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile::CHEMBL1774056

SMILES C[C@H](Nc1nc(Nc2cc(C)n[nH]2)c(F)cc1C#N)c1ccc(F)cn1

InChI Key InChIKey=HIHOEGPXVVKJPP-JTQLQIEISA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50343726   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)
Affinity DataIC50: <1nMAssay Description:Inhibition of human JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)
Affinity DataIC50:  174nMAssay Description:Inhibition of human CDK2/cyclinEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)
Affinity DataIC50: <3nMAssay Description:Inhibition of JAK2 after 60 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)
Affinity DataIC50:  7nMAssay Description:Inhibition of JAK3 after 60 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human InsRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human TRKAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human EphB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human RETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)
Affinity DataIC50:  115nMAssay Description:Inhibition of human FGFR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)
Affinity DataIC50:  129nMAssay Description:Inhibition of human Pyk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)
Affinity DataIC50:  215nMAssay Description:Inhibition of human LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscle, skeletal receptor tyrosine-protein kinase(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)
Affinity DataIC50:  224nMAssay Description:Inhibition of human MuSkMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343726((S)-5-fluoro-2-(1-(5-fluoropyridin-2-yl)ethylamino...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human JAK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed