BDBM50346091 4-(5-ethyl-6-methyl-2-phenylpyrimidin-4-ylamino)benzoic acid::CHEMBL1784109::US10946019, Example 13

SMILES CCc1c(C)nc(nc1Nc1ccc(cc1)C(O)=O)-c1ccccc1

InChI Key InChIKey=JFLSLZLXRTWYJW-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50346091   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Asahi Kasei Pharma

Curated by ChEMBL
LigandPNGBDBM50346091(4-(5-ethyl-6-methyl-2-phenylpyrimidin-4-ylamino)be...)
Affinity DataIC50:  140nMAssay Description:Inhibition of human PDE4B1 incubated for 10 mins using cAMP and [3H]cAMP substratesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM50346091(4-(5-ethyl-6-methyl-2-phenylpyrimidin-4-ylamino)be...)
Affinity DataEC50:  5.00E+3nMAssay Description:The in vitro transactivation assay determined the capacity of the compounds of the invention to activate the Nurr1:RXR heterodimers. Naive SHSY-5Y ce...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Asahi Kasei Pharma

Curated by ChEMBL
LigandPNGBDBM50346091(4-(5-ethyl-6-methyl-2-phenylpyrimidin-4-ylamino)be...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of human PDE4D3 incubated for 10 mins using cAMP and [3H]cAMP substratesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed