BDBM50346235 9-azapaullone::CHEMBL1782168

SMILES O=C1Cc2c([nH]c3ccncc23)-c2ccccc2N1

InChI Key InChIKey=WOUDPYBESPZALS-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50346235   

TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50346235(9-azapaullone | CHEMBL1782168)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of human recombinant CDK2/cyclin A assessed as incorporation of [gamma-33P]-ATP into histone H1 substrate after 30 mins by scintillation c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50346235(9-azapaullone | CHEMBL1782168)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human recombinant CDK5/p25 assessed as incorporation of [gamma-33P]-ATP into histone H1 substrate after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50346235(9-azapaullone | CHEMBL1782168)
Affinity DataIC50:  220nMAssay Description:Inhibition of human recombinant CDK9/cyclin T expressed in insect cells assessed as incorporation of [gamma-33P]-ATP in to pRB fragment (773 to 928) ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform alpha(Sus scrofa)
Trinity College

Curated by ChEMBL
LigandPNGBDBM50346235(9-azapaullone | CHEMBL1782168)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of porcine brain CK1 assessed as incorporation of [gamma-33P]-ATP into RRKHAAIGpSAYSITA substrate after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50346235(9-azapaullone | CHEMBL1782168)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50346235(9-azapaullone | CHEMBL1782168)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli assessed as assessed as incorporation of [gamma-33P]-ATP into myelin bas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50346235(9-azapaullone | CHEMBL1782168)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at NOP receptor in Sprague-Dawley rat vas deferens assessed as effect on electrically stimulated contractionsMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50346235(9-azapaullone | CHEMBL1782168)
Affinity DataIC50:  2.10E+3nMAssay Description:Activity at human B2 receptor transfected in CHO cells assessed as ability to antagonize BK-induced inositol-phosphate accumulationMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50346235(9-azapaullone | CHEMBL1782168)
Affinity DataIC50:  2.10E+3nMAssay Description:Antagonist activity at human M3 receptor assessed as inhibition of carbachol bindingMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50346235(9-azapaullone | CHEMBL1782168)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50346235(9-azapaullone | CHEMBL1782168)
Affinity DataIC50:  3.00E+3nMAssay Description:Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced responseMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50346235(9-azapaullone | CHEMBL1782168)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonistic activity against human CXCR2 in neutrophils assessed as blockade of GROalpha stimulated calcium mobilisation by FLIPRMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50346235(9-azapaullone | CHEMBL1782168)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Plasmodium falciparum GSK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed