BDBM50346347 4-(4-(5-Benzylpyrimidin-2-yl)piperazin-1-yl)quinazoline::CHEMBL1782075::US9994552, Compound 3

SMILES C(c1ccccc1)c1cnc(nc1)N1CCN(CC1)c1ncnc2ccccc12

InChI Key InChIKey=YHUSVRKNGDYNRY-UHFFFAOYSA-N

Data  4 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50346347   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of The Pacific

Curated by ChEMBL
LigandPNGBDBM50346347(4-(4-(5-Benzylpyrimidin-2-yl)piperazin-1-yl)quinaz...)
Affinity DataKd:  460nMAssay Description:Binding affinity to human FLT3 incubated for 1 hr by kinase binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Human)
University of The Pacific

Curated by ChEMBL
LigandPNGBDBM50346347(4-(4-(5-Benzylpyrimidin-2-yl)piperazin-1-yl)quinaz...)
Affinity DataKd:  2.20E+3nMAssay Description:Binding affinity to human KIT incubated for 1 hr by kinase binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit [D816V](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM50346347(4-(4-(5-Benzylpyrimidin-2-yl)piperazin-1-yl)quinaz...)
Affinity DataIC50: >100nMAssay Description:Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
University of The Pacific

Curated by ChEMBL
LigandPNGBDBM50346347(4-(4-(5-Benzylpyrimidin-2-yl)piperazin-1-yl)quinaz...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human KIT using gamma-33P-ATP as substrate by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Human)
University of The Pacific

Curated by ChEMBL
LigandPNGBDBM50346347(4-(4-(5-Benzylpyrimidin-2-yl)piperazin-1-yl)quinaz...)
Affinity DataIC50: >1.00E+3nMAssay Description:Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of The Pacific

Curated by ChEMBL
LigandPNGBDBM50346347(4-(4-(5-Benzylpyrimidin-2-yl)piperazin-1-yl)quinaz...)
Affinity DataIC50:  6.69E+3nMAssay Description:Inhibition of human FLT3 using gamma-33P-ATP as substrate by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed