BDBM50354086 FK-228::Istodax::ROMIDEPSIN
SMILES C\C=C1/NC(=O)[C@@H](CS)NC(=O)[C@H](CC(=O)C[C@H](OC(=O)[C@@H](NC1=O)C(C)C)\C=C\CCS)C(C)C
InChI Key InChIKey=UPCFDQLGZODPFB-BXJZLCHMSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 45 hits for monomerid = 50354086
TargetNuclear receptor corepressor 1(Homo sapiens (Human))
Technical University Of Denmark
Curated by ChEMBL
Technical University Of Denmark
Curated by ChEMBL
Affinity DataKi: 0.150nMAssay Description:Inhibition of GST-tagged recombinant human HDAC3/NcoR1 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate after 15 to 30 minsMore data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataKi: 24.9nMAssay Description:Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataKi: 300nMAssay Description:Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3...More data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibition of HDAC10 (unknown origin) incubated for 30 mins in presence of BSA and DTT by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 647nMAssay Description:Inhibition of HDAC4 (unknown origin) incubated for 30 mins in presence of BSA and DTT by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of HDAC3 (unknown origin) incubated for 30 mins in presence of BSA and DTT by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataIC50: 1.22E+3nMAssay Description:Inhibition of recombinant human HDAC6 after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human HDAC10 after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 11(Homo sapiens (Human))
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human HDAC11 after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of recombinant human HDAC1 after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Affinity DataIC50: 6.07E+3nMAssay Description:Inhibition of recombinant human HDAC2 after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 7(Homo sapiens (Human))
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human HDAC7 after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 9(Homo sapiens (Human))
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human HDAC9 after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 62nMAssay Description:Inhibition of recombinant human HDAC3 after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human HDAC8 after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human HDAC4 after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 5(Homo sapiens (Human))
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human HDAC5 after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of HDAC1 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence methodMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataIC50: 281nMAssay Description:Inhibition of HDAC6 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence methodMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of HDAC8 (unknown origin) incubated for 1 hr by fluor de lys substrate based fluorescence methodMore data for this Ligand-Target Pair
TargetHistone deacetylase 7(Homo sapiens (Human))
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant human HDAC7 using Boc-L-Lys(epsilon-trifluoroacetyl)-AMC as substrate by two-step fluorogenic assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant human HDAC8 using Boc-L-Lys(epsilon-trifluoroacetyl)-AMC as substrate by two-step fluorogenic assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 9(Homo sapiens (Human))
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant human HDAC9 using Boc-L-Lys(epsilon-trifluoroacetyl)-AMC as substrate by two-step fluorogenic assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant human HDAC3/N-CoR2 using Boc-L-Lys(epsilon-trifluoroacetyl)-AMC as substrate by two-step fluorogenic assay in presence of 0...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of recombinant human HDAC3/N-CoR2 using Boc-L-Lys(epsilon-trifluoroacetyl)-AMC as substrate by two-step fluorogenic assay in presence of 0...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of recombinant human HDAC3/N-CoR2 using Boc-L-Lys(epsilon-trifluoroacetyl)-AMC as substrate by two-step fluorogenic assay in presence of 1...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human HDAC3/NCOR2 using Boc-L-Lys(epsilon-trifluoroacetyl)-AMC as substrate by two-step fluorogenic assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant human HDAC4 using Boc-L-Lys(epsilon-trifluoroacetyl)-AMC as substrate by two-step fluorogenic assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of recombinant human HDAC6 using Boc-L-Lys(epsilon-acetyl)-AMC as substrate by two-step fluorogenic assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataEC50: 1.40E+7nMAssay Description:Tested for inhibition of Histone deacetylase 6 induced acetylated tubulin in mammalian cells.More data for this Ligand-Target Pair
Affinity DataIC50: 510nMAssay Description:Inhibition of Histone deacetylase 4 in mammalian cells.More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Affinity DataEC50: 3.60E+4nMAssay Description:Inhibition of Histone deacetylase 1 induced acetylated histone in mammalian cells.More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibitory concentration against human Histone deacetylase 1More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibitory concentration against human Histone deacetylase 6More data for this Ligand-Target Pair
Affinity DataIC50: 510nMAssay Description:Inhibitory concentration against human Histone deacetylase 4More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Affinity DataIC50: 47nMAssay Description:Inhibitory concentration against human Histone deacetylase 2More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Inhibitory concentration against human Histone deacetylase 1 (C151S)More data for this Ligand-Target Pair
Affinity DataIC50: 390nMAssay Description:Inhibition of mouse HDAC6 expressed in human 293T cells using Ac-KGLGK(Ac)-MCA as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 390nMAssay Description:Inhibition of mouse HDAC6 using Ac-KGLGK(Ac)-MCA as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human HDAC1 using Ac-KGLGK(Ac)-MCA as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataIC50: 147nMAssay Description:Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3...More data for this Ligand-Target Pair
TargetHistone deacetylase 11(Homo sapiens (Human))
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of HDAC11 (unknown origin) incubated for 3 hrs in presence of BSA and DTT by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of HDAC1 (unknown origin) incubated for 30 mins in presence of BSA and DTT by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
The Broad Institute Of Harvard And Mit
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Guangzhou Institute Of Biomedicine And Health
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of HDAC2 (unknown origin) incubated for 30 mins in presence of BSA and DTT by fluorescence assayMore data for this Ligand-Target Pair