BDBM50354624 CHEMBL1834422::US10357546, ND-322::US9951035, ND-322 (2)

SMILES Nc1ccc(Oc2ccc(cc2)S(=O)(=O)CC2CS2)cc1

InChI Key InChIKey=AGULWCWMDMKUSF-UHFFFAOYSA-N

Data  13 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50354624   

Target72 kDa type IV collagenase(Homo sapiens (Human))TBA
LigandPNGBDBM50354624(CHEMBL1834422 | US10357546, ND-322 | US9951035, ND...)
Affinity DataKi:  24nMAssay Description:Inhibition of MMP2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))TBA
LigandPNGBDBM50354624(CHEMBL1834422 | US10357546, ND-322 | US9951035, ND...)
Affinity DataKi:  24nMAssay Description:Inhibition of human recombinant MMP2 assessed as hydrolysis of MOCAcPLGLA2pr(Dnp)AR-NH2 by fluorescence spectrofluorometry More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))TBA
LigandPNGBDBM50354624(CHEMBL1834422 | US10357546, ND-322 | US9951035, ND...)
Affinity DataKi:  24nMAssay Description:Competitive inhibition of human MMP-2 assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))TBA
LigandPNGBDBM50354624(CHEMBL1834422 | US10357546, ND-322 | US9951035, ND...)
Affinity DataKi:  100nMAssay Description:Inhibition of MMP14 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))TBA
LigandPNGBDBM50354624(CHEMBL1834422 | US10357546, ND-322 | US9951035, ND...)
Affinity DataKi:  210nMAssay Description:Inhibition of human recombinant MMP14 catalytic domain assessed as hydrolysis of MOCAcPLGLA2pr(Dnp)AR-NH2 by fluorescence spectrofluorometry More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
University of Notre Dame Du Lac

US Patent
LigandPNGBDBM50354624(CHEMBL1834422 | US10357546, ND-322 | US9951035, ND...)
Affinity DataKi:  400nMAssay Description:Human recombinant active MMP-2 and MMP-7, and the catalytic domains of MMP-3 and MMP-14/MT1-MMP were purchased from EMD Chemicals, Inc. (San Diego, C...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University of Notre Dame Du Lac

US Patent
LigandPNGBDBM50354624(CHEMBL1834422 | US10357546, ND-322 | US9951035, ND...)
Affinity DataKi:  870nMAssay Description:The term selective inhibitor as used in reference to MMPs refers to an inhibitor that inhibits the enzymatic activity of one MMP in the presence of o...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University of Notre Dame Du Lac

US Patent
LigandPNGBDBM50354624(CHEMBL1834422 | US10357546, ND-322 | US9951035, ND...)
Affinity DataKi:  870nMAssay Description:Inhibition of human recombinant MMP9 catalytic domain assessed as hydrolysis of MOCAcPLGLA2pr(Dnp)AR-NH2 by fluorescence spectrofluorometry More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University of Notre Dame Du Lac

US Patent
LigandPNGBDBM50354624(CHEMBL1834422 | US10357546, ND-322 | US9951035, ND...)
Affinity DataKi:  870nMAssay Description:Inhibition of MMP9 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University of Notre Dame Du Lac

US Patent
LigandPNGBDBM50354624(CHEMBL1834422 | US10357546, ND-322 | US9951035, ND...)
Affinity DataKi:  870nMAssay Description:Competitive inhibition of human MMP-9 assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University of Notre Dame Du Lac

US Patent
LigandPNGBDBM50354624(CHEMBL1834422 | US10357546, ND-322 | US9951035, ND...)
Affinity DataKi:  2.60E+3nMAssay Description:Human recombinant active MMP-2 and MMP-7, and the catalytic domains of MMP-3 and MMP-14/MT1-MMP were purchased from EMD Chemicals, Inc. (San Diego, C...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil collagenase(Homo sapiens (Human))
University of Notre Dame Du Lac

US Patent
LigandPNGBDBM50354624(CHEMBL1834422 | US10357546, ND-322 | US9951035, ND...)
Affinity DataKi:  2.60E+3nMAssay Description:The term selective inhibitor as used in reference to MMPs refers to an inhibitor that inhibits the enzymatic activity of one MMP in the presence of o...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetStromelysin-1(Homo sapiens (Human))
University Of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50354624(CHEMBL1834422 | US10357546, ND-322 | US9951035, ND...)
Affinity DataKi:  2.34E+4nMAssay Description:Inhibition of human recombinant MMP3 catalytic domain assessed as hydrolysis of MOCAcPLGLA2pr(Dnp)AR-NH2 by fluorescence spectrofluorometry More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))TBA
LigandPNGBDBM50354624(CHEMBL1834422 | US10357546, ND-322 | US9951035, ND...)
Affinity DataIC50:  64nMAssay Description:Inhibition of human full length MMP2 using Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to testing measured for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University of Notre Dame Du Lac

US Patent
LigandPNGBDBM50354624(CHEMBL1834422 | US10357546, ND-322 | US9951035, ND...)
Affinity DataIC50:  611nMAssay Description:Inhibition of human full length MMP9 using Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to testing measured for 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed