BDBM50356066 CHEMBL1911827

SMILES CN[C@@H]1CCN(C1)C(=O)[C@@H](COCc1ccccc1)NC(=O)c1cccnc1Oc1ccc(cc1Cl)C(F)(F)F

InChI Key InChIKey=FFOYIXXRNGMCDQ-NFBKMPQASA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50356066   

TargetCytochrome P450 3A4(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50356066(CHEMBL1911827)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as inhibition of oxidatative metabolism of testosterone after 45 mins by MS analysis in the p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCeramide glucosyltransferase(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50356066(CHEMBL1911827)
Affinity DataIC50:  16nMAssay Description:Inhibition of GCS assessed as amount of UDP-glucose consumed during enzyme-catalyzed reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCeramide glucosyltransferase(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50356066(CHEMBL1911827)
Affinity DataIC50:  5nMAssay Description:Inhibition of GCS activity in human A549 cells assessed as amount of GM1 on the cell membrane after 72 hrs by FL-CTB-based fluorescent microscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed