BindingDB BDBM50357234 CHEMBL1916475

BDBM50357234 CHEMBL1916475

SMILES CCCOCCn1c2cc(nnc2c(NC2CCC(O)CC2)nc1=O)-c1ccc(OC)nc1

InChI Key InChIKey=PRKYJSGLTUYCPF-UHFFFAOYSA-N

Data 15 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50357234

cGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM50357234(CHEMBL1916475)

IC50: 0.0200nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM50357234(CHEMBL1916475)

IC50: >2.00E+3nMAssay Description:Inhibition of PDE1AMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Adenosine receptor A1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM50357234(CHEMBL1916475)

IC50: 440nMAssay Description:Inhibition of adenosine A1 receptorMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM50357234(CHEMBL1916475)

IC50: >2.00E+3nMAssay Description:Inhibition of PDE8BMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM50357234(CHEMBL1916475)

IC50: >2.00E+3nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM50357234(CHEMBL1916475)

IC50: >2.00E+3nMAssay Description:Inhibition of PDE7BMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM50357234(CHEMBL1916475)

IC50: >2.00E+3nMAssay Description:Inhibition of PDE7AMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM50357234(CHEMBL1916475)

IC50: >2.00E+3nMAssay Description:Inhibition of PDE4CMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM50357234(CHEMBL1916475)

IC50: >2.00E+3nMAssay Description:Inhibition of PDE4BMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM50357234(CHEMBL1916475)

IC50: >2.00E+3nMAssay Description:Inhibition of PDE4AMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM50357234(CHEMBL1916475)

IC50: >2.00E+3nMAssay Description:Inhibition of PDE3BMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM50357234(CHEMBL1916475)

IC50: >2.00E+3nMAssay Description:Inhibition of PDE3AMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM50357234(CHEMBL1916475)

IC50: >2.00E+3nMAssay Description:Inhibition of PDE1CMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM50357234(CHEMBL1916475)

IC50: >2.00E+3nMAssay Description:Inhibition of PDE1BMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Acetylcholinesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL

PNG

BDBM50357234(CHEMBL1916475)

IC50: 5.60E+3nMAssay Description:Inhibition of acetylcholinesteraseMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Filter my 15 hits

Targets 15▿
- cGMP-specific 3',5'-cyclic phosphodiesterase 1
- High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A 1
- High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B 1
- Acetylcholinesterase 1
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1
- cAMP-specific 3',5'-cyclic phosphodiesterase 4B 1
- cAMP-specific 3',5'-cyclic phosphodiesterase 4C 1
- cAMP-specific 3',5'-cyclic phosphodiesterase 7B 1
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B 1
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C 1
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 1
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A 1
- cAMP-specific 3',5'-cyclic phosphodiesterase 4A 1
- Adenosine receptor A1 1
- High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A 1
Publications 1▿
- Bioorg Med Chem Lett 21: 6348-52 (2011) 15
Institutions 1▿
- Pfizer 15
Affinity: 0.020 to 5.6E+3 nM▿
- IC50 15
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 0