BDBM50360301 CHEMBL1933288::US9150577, 93

SMILES C[C@@H]1CCNC(=O)c2cc3ccc(cc3n12)C(=O)Nc1nc2ccccc2n1CCCN(C)C

InChI Key InChIKey=ZHMXXVNQAFCXKK-QGZVFWFLSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50360301   

TargetRibosomal protein S6 kinase alpha-2(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50:  1.10nMpH: 7.5Assay Description:Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50:  1nMAssay Description:Inhibition of human RSK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50:  139nMAssay Description:Inhibition of human PRKD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50:  20nMAssay Description:Inhibition of human RSK2-mediated CREB phosphorylation in HLR-CREB cells by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50:  16nMAssay Description:Inhibition of human LRRK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50:  35nMAssay Description:Inhibition of human PRKD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50:  714nMAssay Description:Inhibition of human FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50:  161nMAssay Description:Inhibition of human RETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50:  512nMAssay Description:Inhibition of human CLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50:  112nMAssay Description:Inhibition of human CLK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50:  320nMAssay Description:Inhibition of human FGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50:  956nMAssay Description:Inhibition of human PDGFRaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50:  219nMAssay Description:Inhibition of human PRKD3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed