BDBM50361639 CHEMBL1371684

SMILES Cc1ccc(CSc2nc3CCCc3c(=O)[nH]2)cc1

InChI Key InChIKey=SEZPRMPVJMVCBV-UHFFFAOYSA-N

Data  2 KI  14 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50361639   

TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50361639(CHEMBL1371684)
Affinity DataKi:  800nMAssay Description:Inhibition of full length recombinant human MMP13 expressed in mouse NSO cells using varying levels of fTHP-15 as substrate preincubated for 30 mins ...More data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50361639(CHEMBL1371684)
Affinity DataKi:  824nMAssay Description:Noncompetitive inhibition of human full length recombinant MMP13 using triple-helical fTHP-15 as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2B6(Homo sapiens (Human))
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50361639(CHEMBL1371684)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin) using bupropion substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50361639(CHEMBL1371684)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin) using amodiaquine substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50361639(CHEMBL1371684)
Affinity DataIC50:  8.80E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin) using diclofenac substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50361639(CHEMBL1371684)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin) using (S)-mephentoin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50361639(CHEMBL1371684)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin) using dextromethophan substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50361639(CHEMBL1371684)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using midazolam substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50361639(CHEMBL1371684)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using testosterone substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50361639(CHEMBL1371684)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin) using tacrin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50361639(CHEMBL1371684)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of MMP1 expressed in Escherichia coli using triple-helical fTHP-15 as substrate after 4 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50361639(CHEMBL1371684)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of MMP8 expressed in CHO-K1 cells using triple-helical fTHP-15 as substrate after 4 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50361639(CHEMBL1371684)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of full length recombinant human MMP13 expressed in mouse NSO cells using fTHP-15 as substrate preincubated for 30 mins followed by substr...More data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50361639(CHEMBL1371684)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of MMP-13 (unknown origin)More data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50361639(CHEMBL1371684)
Affinity DataIC50:  2.40E+3nMAssay Description:Non-competitive inhibition of full-length recombinant human MMP-13 assessed as fTHP-15 substrate hydrolysisMore data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50361639(CHEMBL1371684)
Affinity DataIC50:  400nMAssay Description:Inhibition of full-length recombinant human MMP-13 assessed as bovine type-2 collagen hydrolysis after 18 hrs by ELISAMore data for this Ligand-Target Pair